Goblet Cell

Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin MUC5AC. They first made an appearance in Cells at Work. The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under stress.

The term goblet refers to the cell's goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucus laden granules; its basal portion lacks these granules and is shaped like a stem.